|
Symbol Name ID |
Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1) MGI:95819 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Microcephaly |
Stroke |
Spasticity |
Opisthotonus |
Ventriculomegaly |
Polymicrogyria |
Hypoplasia of the corpus callosum |
Cerebral atrophy |
Cerebellar atrophy |
Chorea |
Myoclonus |
EEG abnormality |
Absent speech |
Inappropriate laughter |
Bruxism |
Stereotypical hand wringing |
Self-injurious behavior |
Intellectual disability |
Intellectual disability, severe |
Obstructive sleep apnea |
Hyperreflexia |
Dyskinesia |
Dystonia |
Oculogyric crisis |
Inability to walk |
Hyperkinetic movements |
Epileptic encephalopathy |
Profound global developmental delay |
Severe global developmental delay |
Seizure |
Focal impaired awareness seizure |
Epileptic spasm |
Myoclonic seizure |
| Disease(s) Associated with GRIN1 | |||||||||||||||||||||||||||||||||
| autosomal dominant intellectual developmental disorder 8 | |||||||||||||||||||||||||||||||||
| cerebral infarction | |||||||||||||||||||||||||||||||||
| developmental and epileptic encephalopathy 101 |
| Mouse Phenotypes | nervous system phenotype |
decreased susceptibility to pharmacologically induced seizures |
increased susceptibility to pharmacologically induced seizures |
tonic-clonic seizures |
decreased susceptibility to neuronal excitotoxicity |
abnormal brainstem morphology |
abnormal medium spiny neuron morphology |
abnormal somatosensory cortex morphology |
abnormal primary somatosensory cortex morphology |
absent barrels in primary somatosensory cortex |
abnormal trigeminal nerve morphology |
abnormal nervous system physiology |
abnormal nervous system electrophysiology |
abnormal brain wave pattern |
abnormal single cell response |
abnormal neuron physiology |
reduced NMDA receptor mediated synaptic activity in barrel cortex |
impaired synaptic plasticity |
abnormal excitatory postsynaptic currents |
decreased excitatory postsynaptic current amplitude |
abnormal glutamate-mediated receptor currents |
abnormal AMPA-mediated synaptic currents |
reduced AMPA-mediated synaptic currents |
abnormal NMDA-mediated synaptic currents |
absence of NMDA-mediated synaptic currents |
reduced NMDA-mediated synaptic currents |
abnormal long-term potentiation |
reduced long-term potentiation |
abnormal miniature excitatory postsynaptic currents |
increased miniature excitatory postsynaptic current amplitude |
increased miniature excitatory postsynaptic current frequency |
decreased prepulse inhibition |
absent long-term depression |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||
| Grin1Rgsc174/Grin1Rgsc174 | ||||||||||||||||||||||||||||||||||
| Grin1tm1.1Ese/Grin1tm1.1Ese | ||||||||||||||||||||||||||||||||||
| Grin1tm1.1Phs/Grin1tm1.1Phs | * | |||||||||||||||||||||||||||||||||
| Grin1tm1Bhk/Grin1tm1Bhk | ||||||||||||||||||||||||||||||||||
| Grin1tm1Blt/Grin1tm1Blt | ||||||||||||||||||||||||||||||||||
| Grin1tm1Cur/Grin1tm1Cur | * | |||||||||||||||||||||||||||||||||
| Grin1tm1Jjwd/Grin1tm1Jjwd | ||||||||||||||||||||||||||||||||||
| Grin1tm1Nak/Grin1tm1Nak | ||||||||||||||||||||||||||||||||||
| Grin1tm1Stl/Grin1tm1Stl | ||||||||||||||||||||||||||||||||||
| Grin1tm2Blt/Grin1tm2Blt | ||||||||||||||||||||||||||||||||||
| Grin1Rgsc174/Grin1+ | ||||||||||||||||||||||||||||||||||
| Grin1tm1Cur/Grin1tm1.1Phs | ||||||||||||||||||||||||||||||||||
| Grin1tm1Jjwd/Grin1+ | ||||||||||||||||||||||||||||||||||
| Grin1tm2Slab/Grin1tm1.1Slab | ||||||||||||||||||||||||||||||||||
| Grin1tm1c(EUCOMM)Wtsi/Grin1tm1c(EUCOMM)Wtsi Tg(Slc6a4-cre)ET127Gsat/0 (conditional) |
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| Grik4tm1(cre)Mim/Grik4+ Grin1tm1Mim/Grin1tm1Mim (conditional) |
* | |||||||||||||||||||||||||||||||||
| Grin1tm1Rsp/Grin1tm1Rsp Tg(Gnrh1-cre)1Rsp/0 (conditional) |
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| Grin1tm1Rsp/Grin1tm1Rsp Tg(Camk2a-tTA)1Mmay/? Tg(tetO-cre)LC1Bjd/? (conditional) |
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| Grin1tm1Rsp/Grin1tm1Rsp Tg(Slc6a3-icre)9075Gsc/0 (conditional) |
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| Grin1tm1Yql/Grin1tm1Yql Rgs9tm1.1(cre)Yql/Rgs9+ (conditional) |
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| Grin1tm1Yql/Grin1tm1Yql Tg(Ppp1r2-cre)4127Nkza/0 (conditional) |
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| Grin1tm2Stl/Grin1tm2Stl Tg(Camk2a-cre)T29-1Stl/0 (conditional) |
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| Grin1tm2Stl/Grin1tm2Stl Tg(Grik4-cre)G32-4Stl/0 (conditional) |
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| Grin1tm2Stl/Grin1tm2Stl Tg(Pomc-cre)1Lowl/0 (conditional) |
* | |||||||||||||||||||||||||||||||||
| Grin1tm2Stl/Grin1tm2Stl Tg(Ppp1r2-cre)4127Nkza/0 (conditional) |
* | |||||||||||||||||||||||||||||||||
| Emx1tm1(cre)Ito/Emx1+ Grin1tm1Stl/Grin1tm2Stl (conditional) |
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| Grin1tm1c(EUCOMM)Wtsi/Grin1tm2.1Stl Tg(Slc6a4-cre)ET127Gsat/0 (conditional) |
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| Grin1tm1Rpa/Grin1tm1.1Rpa Slc6a3tm1(cre)Xz/Slc6a3+ (conditional) |
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| Grin1tm1Rpa/Grin1tm1.1Rpa (conditional) | ||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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